
Experience
new energy and strength with micronutrient antioxidants to BOOST your immune system
Over 10 years of clinical
studies have shown K-PAX is a high quality nutritional supplement specifically
developed for people with medical conditions that benefit from aggressive nutritional
support. It
can help increase the energy and strength of anyone who has been suffering
from chronic diseases, recurring infections and weight loss. K-PAX
contains all the essential amino acids, an abundant supply of micronutrients
plus a high-quality protein blend of organic fruits and vegetables with
high antioxidant properties to thoroughly nourish your body. Who
can benefit from K-Pax? The
people who may benefit most from aggressive nutritional support include those
who: -
Have chronic illnesses such as: Cancer, Chronic Fatigue Syndrome, Chronic Hepatitis
- Are prone to frequent Infections such as: HIV, AIDS
- Are
elderly and have many difficult health challenges
- Are on strong
medications struggling to balance their health
- Feel constantly
tired and fatigued
- Wrestle with either obesity or weight loss
- Are
interested in improving their immune system
NOTE:
*These statements have not been evaluated by the Medicines and Healthcare Products
Regulatory Agency or the FDA. This product is not intended to diagnose, treat,
cure or prevent any disease.
What
exactly is in K-PAX and how can it help me? 
Antioxidants:
- In
cases where the immune system may be weakened, such as a viral infection, oxidative
stress occurs, antioxidants play a large role in immune health.
- Antioxidants
are a safe and effective way to reduce oxidative stress and improve health.
- Studies
have shown antioxidants can lead to a reduction in symptoms and fewer days
with symptoms.
Acetyl-L-Carnitine:
- In
vivo and in vitro studies show acetyl-L carnitine decreases the apoptosis of
CD4 and CD8 cells. (Ref. 1)
- Acetyl-L-Carnitine levels are
often lower in those with poor immune health such as in the case of chronic
fatigue syndrome and AIDS. (Ref. 2,3 )
- As we age, oxidative
damage to mitochondria occurs. Acetyl-L-Carnitine increases cellular ATP production,
and has been found in combination with lipoic acid to lower oxidative stress
in animal studies. (Ref. 4,5)
N-Acetyl-L-Cysteine
(and Glutathione): - Supplemental
glutathione is not well absorbed in the body and cannot be absorbed by T-cells.
NAC has been used/shown to increase glutathione levels in the body, and
may also directly improve cellular immunity itself. (Ref. 3,6)
- Often
times those with immunodeficiencies have lower levels of glutathione. Studies
have shown a reduction in glutathione by 10-40% can inhibit T-cell activation
in vitro. (Ref.7)
- Studies done in cases of immune deficiency,
have shown NAC to be an effective antiviral agent and antioxidant, acting
on many different levels. (Ref. 8,9,10,11)
Lipoic
Acid: - Lipoic
acid is used as a potent antioxidant, capable of restoring other antioxidants
such as ascorbate, tocopherol, and glutathione.
- A Hepatitis
C infection is followed by a weakened immune response and oxidative stress,
leading to liver damage and other symptoms. Studies using lipoic acid along with
other antioxidants such as ascorbate, silymarin, and tocopherols, found those
receiving the antioxidant treatment had quicker recovery times and an improvement
in liver enzymes. (Ref. 12,13)
L-Glutamic
Acid: - L-glutamine
is a readily abundant amino acid made in the body. When times of high stress occur,
the body may not be able to meet its glutamine demand. Glutamine is the primary
source of energy for lymphocytes, macrophages, and enterocytes in the small intestine.
(Ref. 3)
- Glutamine has been found to be an immune booster in
those undergoing surgery, chemotherapy and irradiation. (Ref. 14,15,16,17)
- Glutamine is thought to increase immune health by maintaining gut
barrier function and enhancing T-cell function. (Ref. 16,17)
- Currently,
a trial is underway to determine if glutamine and other antioxidant therapy
is effective at reducing deaths due to oxidative stress in critically-ill patients.18
Micronutrients:
- It
is well known micronutrients play an important part in immune health. When
the immune system is stressed or weak, micronutrients have been shown to be beneficial
in recovery times and cell functions, taken prophalactily micronutrients can
help strengthen the immune system, lessening the chance for illness. While
the mechanisms of each micronutrient are complex and some not widely understood,
micronutrient therapy has been used in main stream medicine and continues to be
studied.
- 51 critically ill patients were given either 50 mg or 100 mg
of vitamin B6 or placebo. Those receiving the vitamin B6 saw increases in T-lymphocyte
and T-helper cell numbers and the percentage of T-suppressor cell significantly
increased. No significant changes were found in the placebo group. (Ref.
19)
- Selenium is used is for the functioning of neutrophils,
macrophages, NK cells, T cells and other immune mechanisms. (Ref. 20,21,22)
- Low levels of zinc have been found in those with immunodefiencies.
Supplementation with zinc for one to two months has been able to restore immune
responses and decrease infections. (Ref. 21)
- Vitamin
A can act directly through its functions in the metabolism of certain
immune cells. Antibody mediated immunity has been found to be impaired with
vitamin A deficiency. (Ref. 22)
- Vitamin C is
found in high concentrations in leukocystes and used quickly during an infection.
One study found a high dose of vitamin C was able to increase NK activity.
(Ref. 22)
- Vitamin E deficiencies results in free
radical induced damage to red blood cells. vitamin E has been shown to increase
the CD4/CD8 ratio and enhance T-cell proliferation in healthy individuals.
(Ref. 22)
- Vitamin D has been found to modulate T-cell
responses. In vitro, vitamin D was found to have some effects on lymphocyte
function as well. (Ref. 23)
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How
much should I use?
For
best results, we always recommend you consult your physician or health practitioner
for your individual use. The following are general guidlines. RECOMMENDED
DOSE: Capsules:
For
optimal results take with food and observe these dosing guidelines:
To Maintain your current health status: - Weight
<120 lbs, take 4 capsules 1 time per day.
- Weight
>120 lb, take
8 capsules 1 time per day.
To
Improve your current health status: - Weight
<120 lbs, take 4 capsules 2 times per day.
- Weight
>120 lbs, take 8 capsules 2 times per day.
View
supplement facts. Must
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Powder:
Mix
1 rounded scoop in 8 oz. of water or your favorite fruit juice. Stir to mix or
shake in a closed container with ice. Dilute with water if desired. May
also be mixed with yogurt, pudding, apple sauce, and blender drinks. CONTRAINDICATIONS:
Class 1. If you are pregnant or nursing consult your health care provider before
taking this product. This
product contains the following potential allergen: Soy.

Back
to top What
references did you use? The
following references were provided by Ortho Molecular Products, the manufacturer
of K-PAX. 1.
Di, M.L.; Moretti, S. et al. Acetyl-L-carnitine administration increases insulin-like
growth factor 1 levels in asymptomatic HIV-1-infected subjects: correlation with
its suppressive effect on lymphocyte apoptosis and ceramide generation. Clin Immunol.
1999; 92(1):103-110. 2.
Vermeulen, R.C. and Scholte, H.R. Azithromycin in chronic fatigue syndrome (CFS),
an analysis of clinical data. J Transl Med. 2006; 4:34 3.
Patrick, L. Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid,
L-glutamine, and L-carnitine. Altern Med Rev. 2000; 5(4):290-305. 4.
Shigenaga, M.K.; Hagen, T.M.; and Ames, B.N. Oxidative damage and mitochondrial
decay in aging. Proc Natl Acad Sci U S A. 1994; 91(23):10771-10778. 5.
Hagen, T.M.; Liu, J. et al. Feeding acetyl-L-carnitine and lipoic acid to old
rats significantly improves metabolic function while decreasing oxidative stress.
Proc Natl Acad Sci U S A. 2002; 99(4):1870-1875. 6.
De Rosa, S.C.; Zaretsky, M.D. et al. N-acetylcysteine replenishes glutathione
in HIV infection. Eur J Clin Invest. 2000; 30(10):915-929. 7.
Staal, F.J.; Roederer, M. et al. Intracellular thiols regulate activation of nuclear
factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad
Sci U S A. 1990; 87(24):9943-9947. 8.
Grandjean, E.M.; Berthet, P. et al. Efficacy of oral long-term N-acetylcysteine
in chronic bronchopulmonary disease: a meta-analysis of published double-blind,
placebo-controlled clinical trials. Clin Ther. 2000; 22(2):209-221. 9.
Gunduz, H.; Karabay, O. et al. N-acetyl cysteine therapy in acute viral hepatitis.
World J Gastroenterol. 2003; 9(12):2698-2700. 10.
Garozzo, A.; Tempera, G. et al. N-acetylcysteine synergizes with oseltamivir in
protecting mice from lethal influenza infection. Int J Immunopathol Pharmacol.
2007; 20(2):349-354. 11.
Ghezzi, P. and Ungheri, D. Synergistic combination of N-acetylcysteine and ribavirin
to protect from lethal influenza viral infection in a mouse model. Int J Immunopathol
Pharmacol. 2004; 17(1):99-102. 12.
Berkson, B.M. A conservative triple antioxidant approach to the treatment of hepatitis
C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium:
three case histories. Med Klin (Munich). 1999; 94 Suppl 3:84-89. 13.
Melhem, A.; Stern, M. et al. Treatment of chronic hepatitis C virus infection
via antioxidants: results of a phase I clinical trial. J Clin Gastroenterol. 2005;
39(8):737-742. 14.
Wang, W.S.; Lin, J.K. et al. Oral glutamine is effective for preventing oxaliplatin-induced
neuropathy in colorectal cancer patients. Oncologist. 2007; 12(3):312-319. 15.
Zheng, Y.M.; Li, F. et al. Glutamine dipeptide for parenteral nutrition in abdominal
surgery: a meta-analysis of randomized controlled trials. World J Gastroenterol.
2006; 12(46):7537-7541. 16.
O'Riordain, M.G.; De, B.A.; and Fearon, K.C. Effect of glutamine on immune function
in the surgical patient. Nutrition. 1996; 12(11-12 Suppl):S82-S84. 17.
O'Riordain, M.G.; Fearon, K.C. et al. Glutamine-supplemented total parenteral
nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal
resection. Ann Surg. 1994; 220(2):212-221. 18.
Heyland, D.K.; Dhaliwal, R. et al. REducing Deaths due to OXidative Stress (The
REDOXS Study): Rationale and study design for a randomized trial of glutamine
and antioxidant supplementation in critically-ill patients. Proc Nutr Soc. 2006;
65(3):250-263. 19.
Cheng, C.H.; Chang, S.J. et al. Vitamin B6 supplementation increases immune responses
in critically ill patients. Eur J Clin Nutr. 2006; 60(10):1207-1213. 20.
Kidd, P. Th1/Th2 balance: the hypothesis, its limitations, and implications for
health and disease. Altern Med Rev. 2003; 8(3):223-246. 21.
Ferencik, M. and Ebringer, L. Modulatory effects of selenium and zinc on the immune
system. Folia Microbiol (Praha). 2003; 48(3):417-426. 22.
Field, C.J.; Johnson, I.R.; and Schley, P.D. Nutrients and their role in host
resistance to infection. J Leukoc Biol. 2002; 71(1):16-32. 23.
Adams, J.S.; Liu, P. et al. Vitamin D in Defense of the Human Immune Response.
Ann N Y Acad Sci. 2007; information for health care professionals only Back
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